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Chromatographic Columns

Chromatographic Columns

A series of long-chain functional silanes including octyl, dodecyl and octadecyl silanes have been systematically synthesized by Co-Formula technician. These functional silanes have superior hydrophobicity. They are mainly serving as surface modifiers for nanoparticles and fillers, especially suitable for the processing of chromatographic columns.

Listed long-chain silanes as below are specially developed for applications in the market of chromatographic columns.

Trade Code

Chemical Name

CAS No.

Molecular Formula

CFS-088

Octadecyldimethylchlorosilane

18643-08-8

C20H43ClSi

CFS-317

Dodecyldimethylchlorosilane

66604-31-7

C14H30ClSi

CFS-840

Octyldimethylchlorosilane

18162-84-0

C10H23ClSi

CFS-049

Octadecyltrichlorosilane

112-04-9

C18H37Cl3Si

CFS-4724

Dodecyltrichlorosilane

4484-72-4

C12H25Cl3Si

CFS-3669

Octyltrichlorosilane

5283-66-9

C8H17Cl3Si


Co-Formula octyl, dodecyl and octadecyl functional silanes are generally used for silica modification, micro and nanoparticles treatment and molecular monolayers generation. There are several kinds of chloro silanes and alkoxy silanes which can react with silanol groups of the bonded surface and obtain Si-O-Si-C bonding. Silylation is the best way to deactivate the inner wall of capillary column. Silylation reagents react with the silanol group of the inner surface of the column to achieve deactivation and passivation. Dimethyldichlorosilane and methyl hydrogen silicone fluid have been proved to be suitable for deactivation and passivation of elastic quartz capillary columns.

Chromatographic columns are the core part of GC (gas chromatography). The separation performance of GC depends on the selectivity of stationary liquids in the chromatographic column. There are many substances that can be used as stationary phases of GC. Among them, silicone fluids or siloxanes are the most commonly used stationary liquids.

Good separation performance of Co-Formula methyl silicone fluids has been verified by chromatography. They have excellent thermal stability and can work under the temperature ranging from -50℃ to 350℃. Temperature has little influence on the viscosity of silicone fluids. The superior selectivity makes Co-Formula methyl silicone fluids suitable for the analysis of many high boiling point polar compounds.